Solid-phase parallel synthesis of trisubstituted dihydroimidazolyl dihydroquinoxalin-2(1H)-ones
β Scribed by Achyuta N Acharya; John M Ostresh; Richard A Houghten
- Book ID
- 108371465
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 107 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0040-4020
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π SIMILAR VOLUMES
The solid phase synthesis of 2,4,5-trisubstituted thiomorpholin-3-ones is described. Starting from a resin-bound protected cysteine, and employing reductive alkylation and amide formation, thiomoq~holin-3one derivatives have been synthesized through intramolecular thioether formation in good yield a
Cyanoacetic acid was loaded on Wang resin and C-acylated using acid anhydrides and triethylamine as base. Resin cleavage with concomitant decarboxylation produces 13-keto nitriles. In the case of isatoic anhydrides, the resin-bound acylated intermediates undergo cyclative cleavage upon heating, lead