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Solid-phase combinatorial synthesis of 4-hydroxyquinolin-2(1H)-ones

✍ Scribed by Mui Mui Sim; Cheng Leng Lee; A. Ganesan

Book ID
104259715
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
192 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

Cyanoacetic acid was loaded on Wang resin and C-acylated using acid anhydrides and triethylamine as base. Resin cleavage with concomitant decarboxylation produces 13-keto nitriles. In the case of isatoic anhydrides, the resin-bound acylated intermediates undergo cyclative cleavage upon heating, leading to 4hydroxyquinolin-2(1H)-ones.

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