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Efficient solid-phase synthesis of 4,5-dihydro-1,2,4-triazin-6(1H)-ones

✍ Scribed by Damien Boeglin; Sonia Cantel; Jean Martinez; Jean-Alain Fehrentz

Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 121 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)02591-1

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✦ Synopsis

A new and easy protocol for the formation of substituted 4,5-dihydro-1,2,4-triazin-6(1H)-ones was developed on solid support. The heterocyclic compounds were formed by nucleophilic reaction of hydrazine on thioamide esters. As cyclization was concomitant with cleavage from the support, substituted 4,5-dihydrotriazinones were obtained in high purity.

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