A new and easy protocol for the formation of substituted 4,5-dihydro-1,2,4-triazin-6(1H)-ones was developed on solid support. The heterocyclic compounds were formed by nucleophilic reaction of hydrazine on thioamide esters. As cyclization was concomitant with cleavage from the support, substituted 4
✦ LIBER ✦
Solid-phase synthesis of 1-substituted 4,5-dihydro-1,2,4-triazin-6-ones
✍ Scribed by Blanca Martı́nez-Teipel; Enrique Michelotti; Martha J Kelly; Damian G Weaver; Francis Acholla; Kebede Beshah; Jordi Teixidó
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 63 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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