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Solid-phase synthesis of functionalized 1,2,4-triazin-6-ones

✍ Scribed by Benjamin E Blass; Keith R Coburn; Amy L Faulkner; Song Liu; Adam Ogden; David E Portlock; Anil Srivastava

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
107 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

The solid supported synthesis of functionalized 1,2,4-triazin-6-ones from resin bound amino acids and acid chlorides is described. A thioamide intermediate is generated with Lawesson's reagent, and the final products are cyclized and cleaved from resin with hydrazine. The products are obtained in good yield and purity.

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