The solid phase synthesis of 2,4,5-trisubstituted thiomorpholin-3-ones is described. Starting from a resin-bound protected cysteine, and employing reductive alkylation and amide formation, thiomoq~holin-3one derivatives have been synthesized through intramolecular thioether formation in good yield a
✦ LIBER ✦
Solid-phase synthesis of 1,2,5-trisubstituted imidazolidin-4-ones
✍ Scribed by Lan-Ying Qin; Andrew G. Cole; Axel Metzger; Linda O’Brien; Xiling Sun; Jin Wu; Yan Xu; Kai Xu; Ying Zhang; Ian Henderson
- Book ID
- 108285302
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- French
- Weight
- 273 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0040-4039
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## Abstract Facile, alternative synthetic routes to **6**, **(R)‐6**, and **(S)‐6**‐3‐benzyl‐__N__‐(2,6‐dimethylphenyl)‐1,3‐oxazolidine‐4‐carboxamides (**6**), a chiral oxazolidine derivative of tocainide, are reported. The synthetic routes described herein also afforded **11**‐, **(R)‐11**‐, and *