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Solid-phase synthesis of 1,2,5-trisubstituted imidazolidin-4-ones

✍ Scribed by Lan-Ying Qin; Andrew G. Cole; Axel Metzger; Linda O’Brien; Xiling Sun; Jin Wu; Yan Xu; Kai Xu; Ying Zhang; Ian Henderson


Book ID
108285302
Publisher
Elsevier Science
Year
2009
Tongue
French
Weight
273 KB
Volume
50
Category
Article
ISSN
0040-4039

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## Abstract Facile, alternative synthetic routes to **6**, **(R)‐6**, and **(S)‐6**‐3‐benzyl‐__N__‐(2,6‐dimethylphenyl)‐1,3‐oxazolidine‐4‐carboxamides (**6**), a chiral oxazolidine derivative of tocainide, are reported. The synthetic routes described herein also afforded **11**‐, **(R)‐11**‐, and *