The solid phase synthesis of 2,4,5-trisubstituted thiomorpholin-3-ones is described. Starting from a resin-bound protected cysteine, and employing reductive alkylation and amide formation, thiomoq~holin-3one derivatives have been synthesized through intramolecular thioether formation in good yield a
Solid phase synthesis of 1,3,5-trisubstituted pyridin-2-ones
โ Scribed by James A. Linn; Samuel W. Gerritz; Anthony L. Handlon; Clifton E. Hyman; Dennis Heyer
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 283 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0040-4039
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