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Solid phase synthesis of a 1,3,5-trisubstituted pyridinium salt library

✍ Scribed by M. Amparo Lago; Thomas T. Nguyen; Pradip Bhatnagar

Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 199 KB
Volume: 39
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(98)00683-2

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✦ Synopsis

The synthesis of a 1,3,5-trisubstituted pyridinium salt combinatorial array containing two variable groups was accomplished in good yields. This entailed the incorporation of 5-bromonicotinic acid onto the resin, followed by Pd(0) catalyzed Suzuki coupling, then alkylation of the pyridine nitrogen and finally cleavage from the resin. A mix and split scheme was also carded out.

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