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Solid-phase synthesis of trisubstituted guanidines

โœ Scribed by David H. Drewry; Samuel W. Gerritz; James A. Linn

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
233 KB
Volume
38
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

The solid-phase synthesis of trisubsituted guanidines is reported via aza-Wittig coupling of a solid-supported alkyl iminophosphorane with an aryl or alkyl isothiocyanate to generate the corresponding solid-supported carbodiimide which is then reacted with a primary or secondary amine to afford the desired trisubst~tuted guanidines.

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