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Solid-phase synthesis of disubstituted guanidines

✍ Scribed by Patrick C. Kearney; Monica Fernandez; John A. Flygare

Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 227 KB
Volume: 39
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(98)00373-6

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✦ Synopsis

A method for the solid-phase synthesis of disubstituted guanidines is reported. In this procedure, polymer-bound aryl or alkyl amines are converted to methyl isothioureas in three steps and treated with primary and secondary amines to form the disubstituted guanidine products.

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