Highly diastereoselective alkylation (296% de) of a-lithiated N-[N'-bis(methylthio)---methyleneglycyl~-~-2,5-bis~methoxymethoxymethyl~pyrrolidine and subsequent hydrolysis gave a-amino acids of high optical purity. An unusual amino acid (2S,9\_S)-2-amino-8-oxo-9,10epoxydecanoic acid was synthesized
โฆ LIBER โฆ
A simple solid-phase synthesis of disubstituted guanidines using Rink amide resin as an amine component
โ Scribed by Min Li; Lawrence J Wilson; David E Portlock
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 86 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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Methods for the synthesis of chloromethyl and bromomethyl equivalents of Wang's resin are described. To explore the utility of this acid cleavable resin, amines were immobilized through the nitrogen atom, further functionalized, and then cleaved under acid conditions.