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Solid phase synthesis of 2,4,5-trisubstituted thiomorpholin-3-ones

โœ Scribed by Adel Nefzi; Marc Giulianotti; Richard A. Houghten

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
170 KB
Volume
39
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

The solid phase synthesis of 2,4,5-trisubstituted thiomorpholin-3-ones is described. Starting from a resin-bound protected cysteine, and employing reductive alkylation and amide formation, thiomoq~holin-3one derivatives have been synthesized through intramolecular thioether formation in good yield and high purity.

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