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Synthesis of 3,4,5-trisubstituted cyclohexanones by cycloaddition to solid phase 2-aminobutadienes

โœ Scribed by Melanie Crawshaw; Nicholas W. Hird; Kazuyuki Irie; Katsunori Nagai


Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
194 KB
Volume
38
Category
Article
ISSN
0040-4039

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Solid phase synthesis of 2,4,5-trisubsti
โœ Adel Nefzi; Marc Giulianotti; Richard A. Houghten ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 170 KB

The solid phase synthesis of 2,4,5-trisubstituted thiomorpholin-3-ones is described. Starting from a resin-bound protected cysteine, and employing reductive alkylation and amide formation, thiomoq~holin-3one derivatives have been synthesized through intramolecular thioether formation in good yield a