Solid phase synthesis of 2,4,5-trisubsti
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Adel Nefzi; Marc Giulianotti; Richard A. Houghten
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Article
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1998
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Elsevier Science
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French
โ 170 KB
The solid phase synthesis of 2,4,5-trisubstituted thiomorpholin-3-ones is described. Starting from a resin-bound protected cysteine, and employing reductive alkylation and amide formation, thiomoq~holin-3one derivatives have been synthesized through intramolecular thioether formation in good yield a