Solid phase synthesis of 1,4-benzothiaze
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Adel Nefzi; Nhi A Ong; Marc A Giulianotti; John M Ostresh; Richard A Houghten
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Article
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1999
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Elsevier Science
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French
⚖ 199 KB
The solid phase synthesis of 1,4-benzothiazepin-5-one derivatives, resulting from the reaction of resin-bound protected cysteine with 2-fluoro-5-nitro-benzoic acid followed by a reductive aikylation and an intra molecular cyclization, is described.