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Solid-Phase Synthesis of Trisubstituted Benzo[1,4]-Diazepin-5-one Derivatives

✍ Scribed by Fülöpová, Veronika; Gucký, Tomáš; Grepl, Martin; Soural, Miroslav


Book ID
118121880
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
645 KB
Volume
14
Category
Article
ISSN
2156-8952

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Solid phase synthesis of 1,4-benzothiaze
✍ Adel Nefzi; Nhi A Ong; Marc A Giulianotti; John M Ostresh; Richard A Houghten 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 199 KB

The solid phase synthesis of 1,4-benzothiazepin-5-one derivatives, resulting from the reaction of resin-bound protected cysteine with 2-fluoro-5-nitro-benzoic acid followed by a reductive aikylation and an intra molecular cyclization, is described.