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Remote operated synthesis of 2-deoxy-2-[18F]Fluoro-d-glucose

โœ Scribed by Mirko Diksic; Dean Jolly; Dean Jolly


Publisher
Elsevier Science
Year
1986
Weight
227 KB
Volume
37
Category
Article
ISSN
0883-2889

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Labeled 2-deoxy-D-glucose analogs. 18F-l
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## Abstract A convenient method for the synthesis of ^18^Fโ€2โ€deoxyโ€2โ€fluoroโ€Dโ€glucose (4) and ^18^Fโ€2โ€deoxyโ€2โ€fluoroโ€Dโ€mannose (8) by the direct fluorination of 3,4,6โ€triโ€0โ€acetylโ€Dโ€glucal with ^18^Fโ€F~2~ is described. ^14^Cโ€2โ€deoxyโ€2โ€fluoroโ€Dโ€glucose has been synthesized from ^14^Cโ€3,4,6โ€triโ€0โ€ace

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A combined study of the labelling methods of two important glucose-derivatives i.e. [18F]2-deoxy-2-fluoro-D-glucose ([laF]2-FDG) and [lSF]3-deoxy-3-fluoro-D-glucose ([18F]3-FDG) is described. Using [ISF]fluoride as reacting agent produced in a water target via the 180(p, n)'SF and ~60(3He, p)~SF rea

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18F labelled compounds. Thus, a synthetic route to ("F)2-Deoxy-2-fluoro-~glucose was studied which should run as simple and hot-cell-friendly as possible and shc~uld deliver the sugar with high yield and free of diastereomers, even by use of high I8F acitivities

Contamination of 2-deoxy-2-[18F]fluoro-d
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The presence of 2-deoxy-2-['sF]fluoro-D-mannose (['sF]FDM) in 2-deoxy-2-['\*F]fluoro-o-glucose (['aF]FDG) prepared by the reaction of 3,4,6-tri-0-acetyi-D-glucal (TAG) with ['\*F]acetyl hypofluorite ([r\*F]CHsCOOF) or ['sF]Fr was quantified by radio HPLC analysis of reacetylated ['\*F]FDG. The solve