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Labeled 2-deoxy-D-glucose analogs. 18F-labeled 2-deoxy-2-fluoro-D-glucose, 2-deoxy-2-fluoro-D-mannose and 14C-2-deoxy-2-fluoro-D-glucose

✍ Scribed by T. Ido; C-N. Wan; V. Casella; J. S. Fowler; A. P. Wolf; M. Reivich; D. E. Kuhl

Publisher
John Wiley and Sons
Year
1978
Tongue
French
Weight
337 KB
Volume
14
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

A convenient method for the synthesis of ^18^F‐2‐deoxy‐2‐fluoro‐D‐glucose (4) and ^18^F‐2‐deoxy‐2‐fluoro‐D‐mannose (8) by the direct fluorination of 3,4,6‐tri‐0‐acetyl‐D‐glucal with ^18^F‐F~2~ is described. ^14^C‐2‐deoxy‐2‐fluoro‐D‐glucose has been synthesized from ^14^C‐3,4,6‐tri‐0‐acetyl‐D‐glucal (from D‐[^14^c(U)]‐glucose) by fluorination with F~2~ (Method 1) and CF~3~OF (Method 2). These labeled analogs of 2‐deoxy‐D‐glucose were required for the study of local cerebral glucose metabolism.

📜 SIMILAR VOLUMES

Synthesis of (18F)2-deoxy-2-fluoro-D-glu
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✍ Mario Argentini; Thomas Mäder; Regin Weinreich 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 French ⚖ 50 KB

18F labelled compounds. Thus, a synthetic route to ("F)2-Deoxy-2-fluoro-~glucose was studied which should run as simple and hot-cell-friendly as possible and shc~uld deliver the sugar with high yield and free of diastereomers, even by use of high I8F acitivities

Gas-liquid chromatographic determination
Gas-liquid chromatographic determination of relative amounts of 2-deoxy-2-flouro-D-glucose and 2-deoxy-2-fluoro-D-mannose synthesized from various methods
✍ Chyng-Yann Shiue; Joanna S. Fowler; Alfred P. Wolf; David Alexoff; Robert R. Mac 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 French ⚖ 218 KB

## SmQIARY A column (6 f t x 1/8 i n ) c o n t a i n i n g 4% SE-30 + 6% OV-210 on Chromosorb W-HP 80/100 mesh was employed t o determine t h e r e l a t i v e amounts of 2-deoxy-2-fluoro-D-glucose (2-PDG) and 2-deoxy-2-fluoro-D-mannose (2-FPM) s y n t h e s i z e d using various methods. c o n t

A rapid synthesis of 2-deoxy-2-fluoro-d-
A rapid synthesis of 2-deoxy-2-fluoro-d-glucose from xenon difluoride suitable for labelling with 18F
✍ Chyng-Yann Shiue; K.-C.; Alfred P. Wolf 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 French ⚖ 256 KB

## Abstract A rapid synthesis of 2‐deoxy‐2‐fluoro‐D‐glucose **(3)** from xenon difluoride is described. Reaction of 3,4,6‐tri‐O‐acetyl‐D‐glucal **(1)** with xenon difluoride in ethyl ether in the presence of BF~3~·OEt~2~ for 20 minutes gave 2‐deoxy‐2‐fluoro‐ 3,4,6‐tri‐O‐acetyl‐D‐glucopyranosyl fluo