Synthesis of (18F)2-deoxy-2-fluoro-D-glucose using high 81F activities
✍ Scribed by Mario Argentini; Thomas Mäder; Regin Weinreich
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- French
- Weight
- 50 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
18F labelled compounds. Thus, a synthetic route to ("F)2-Deoxy-2-fluoro-~glucose was studied which should run as simple and hot-cell-friendly as possible and shc~uld deliver the sugar with high yield and free of diastereomers, even by use of high I8F acitivities
📜 SIMILAR VOLUMES
Two alternative routes to no-carrier-added synthesis of 2-deoxy-2-[ "F] f luoro-D-glucose (2-18FDG) involving nucleophilic displacements of methyl 3-0-benzyl-4,6-0-benzylidene-2-O-(trifluoromethanesulfonyl~-~-D-mannopyranoside (1) and l,6-anhydro-3,4-di-0-benzyl-2-O-(trifluoromethanesulfonyl)-~-D-ma
## Abstract A convenient method for the synthesis of ^18^F‐2‐deoxy‐2‐fluoro‐D‐glucose (4) and ^18^F‐2‐deoxy‐2‐fluoro‐D‐mannose (8) by the direct fluorination of 3,4,6‐tri‐0‐acetyl‐D‐glucal with ^18^F‐F~2~ is described. ^14^C‐2‐deoxy‐2‐fluoro‐D‐glucose has been synthesized from ^14^C‐3,4,6‐tri‐0‐ace
A nucleophilic radiofluorination of methyl 3,4-0-isopropylidene-2-0-(trif luoromethanesulfonyl) -6-O-trityl-/3-D-talopyranoside (1) with aninopolyether Hydrolysis of 2 with 6N HCl followed by passage through an ion retardation resin column and a neutral alumina column gave 2-deoxy-2-[18F1 f luoro-
455 2 -( 1 8 F ) f l u o r o -2 -d e o x y -d -g l u c o s e p r o d u c e d w i t h a n e l e c t r o n a c c e l e r a t o r .