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A new synthesis of 2-deoxy-2-[18f]fluoro-D-galactose using [18f]fluoride ion

✍ Scribed by Terushi Haradahira; Minoru Maeda; Yasunobu Kai; Masaharu Kojima

Publisher
John Wiley and Sons
Year
1988
Tongue
French
Weight
357 KB
Volume
25
Category
Article
ISSN
0022-2135

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✦ Synopsis

A nucleophilic radiofluorination of methyl 3,4-0-isopropylidene-2-0-(trif luoromethanesulfonyl) -6-O-trityl-/3-D-talopyranoside

(1) with aninopolyether

Hydrolysis of 2 with 6N HCl followed by passage through an ion retardation resin column and a neutral alumina column gave 2-deoxy-2-[18F1 f luoro-D-galactose (2- "FDGal) in 36-39% overall radiochemical yield without correction for decay. The total preparation time was about 90 min from start of the radiofluorination.

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