A nucleophilic radiofluorination of methyl 3,4-0-isopropylidene-2-0-(trif luoromethanesulfonyl) -6-O-trityl-/3-D-talopyranoside (1) with aninopolyether Hydrolysis of 2 with 6N HCl followed by passage through an ion retardation resin column and a neutral alumina column gave 2-deoxy-2-[18F1 f luoro-
Synthesis of 2-deoxy-2-[18F]-fluoro-β-mannosyl [18F]-fluoride as a potential imaging probe for Glycosidases
✍ Scribed by John D. McCarter; Michael J. Adam; Stephen G. Withers
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- French
- Weight
- 221 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
The mechanisms‐based glycosidase inhibitor 2‐deoxy‐2‐[^18^F]‐fluoro‐β‐mannosyl [^18^F]‐fluoride was synthesized and its covalent binding to Agrobacterium β‐glucosidase was demonstrated in vitro.
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