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Enzymatic synthesis and biodistribution in mice of β-O-D-galactopyranosyl-(1,4′)-2′-[18F]fluoro-2′-deoxy-D-glucopyranose (2′-[18F]fluorodeoxylactose]

✍ Scribed by G. Bormans; A. Verbruggen

Publisher
John Wiley and Sons
Year
2001
Tongue
French
Weight
100 KB
Volume
44
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

We have synthesized β‐O‐D‐galactopyranosyl‐(1,4′)‐2′‐[^18^F]fluoro‐2′‐deoxy‐D‐glucopyranose (2′‐[^18^F]fluorodeoxylactose, ^18^FDL) using an enzymatic method starting from ^18^FDG in order to evaluate this compound with regard to its usefulness for in vivo visualization of the expression of the LacZ gene. Incubation of ^18^FDL with β‐galactosidase results in the formation of ^18^FDG. Biodistribution studies in normal mice showed that ^18^FDL is cleared by urinary excretion and is not retained in any tissue. Biodistribution in Rosa‐26 mice is identical to the biodistribution in normal mice, suggesting that ^18^FDL is not able to cross the cell membrane. Copyright © 2001 John Wiley & Sons, Ltd.

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