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A general synthesis of 2′-deoxy-2′-[18F]fluoro-1-β-D-arabinofuranosyluracil and its 5-substituted nucleosides

✍ Scribed by Mian M. Alauddin; Peter S. Conti; John D. Fissekis

Publisher
John Wiley and Sons
Year
2003
Tongue
French
Weight
77 KB
Volume
46
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Several 2′‐deoxy‐2′‐[^18^F]fluoro‐1‐β‐D‐arabinofuranosyluracil derivatives have been synthesized. Coupling of 1‐bromo‐2‐deoxy‐2‐[^18^F]fluoro‐3,5‐di‐O‐benzoyl‐α‐D‐arabinofuranose 2 with protected uracil derivatives 3a–e followed by hydrolysis and high‐performance liquid chromatography purification produced the radiolabeled nucleosides 4a–e in 15–30% yield (d. c.), >99% radiochemical purity and 55.5–103.6 GBq/µmol specific activities. Copyright © 2003 John Wiley & Sons, Ltd.

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