✦ LIBER ✦

A rapid synthesis of 2-deoxy-2-fluoro-d-glucose from xenon difluoride suitable for labelling with 18F

✍ Scribed by Chyng-Yann Shiue; K.-C.; Alfred P. Wolf

Publisher: John Wiley and Sons
Year: 1983
Tongue: French
Weight: 256 KB
Volume: 20
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580200202

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A rapid synthesis of 2‐deoxy‐2‐fluoro‐D‐glucose (3) from xenon difluoride is described. Reaction of 3,4,6‐tri‐O‐acetyl‐D‐glucal (1) with xenon difluoride in ethyl ether in the presence of BF~3~·OEt~2~ for 20 minutes gave 2‐deoxy‐2‐fluoro‐ 3,4,6‐tri‐O‐acetyl‐D‐glucopyranosyl fluoride (2) in 70‐80% chemical yield. Hydrolysis of 2 with 2 N HCl gave 2‐deoxy‐2‐fluoro‐D‐glucose (3) in 50% overall chemical yield in a synthesis time of 60 minutes. Preliminary results indicate that this method can be used to synthesize 2‐deoxy‐2‐ [^18^F] fluoro‐D‐glucose.

📜 SIMILAR VOLUMES

Rapid synthesis of 2-deoxy-D (1-14C) glu

Rapid synthesis of 2-deoxy-D (1-14C) glucose suitable for labelling with 11C

✍ Geneviève Mestelan; Francis Aubert; Jean-Pierre Beaucourt; Dominique Comar; Loui 📂 Article 📅 1979 🏛 John Wiley and Sons 🌐 French ⚖ 327 KB

A Solid-Phase Route to 18F-Labeled Trace

A Solid-Phase Route to 18F-Labeled Tracers, Exemplified by the Synthesis of [18F]2-Fluoro-2-deoxy-D-glucose

✍ Lynda J. Brown; Denis R. Bouvet; Sue Champion; Alex M. Gibson; Yulai Hu; Alex Ja 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 203 KB 👁 2 views

A Solid-Phase Route to 18F-Labeled Trace

A Solid-Phase Route to 18F-Labeled Tracers, Exemplified by the Synthesis of [18F]2-Fluoro-2-deoxy-D-glucose

✍ Lynda J. Brown; Denis R. Bouvet; Sue Champion; Alex M. Gibson; Yulai Hu; Alex Ja 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 202 KB 👁 2 views

Synthesis of 2′-Deoxy-2′-fluoro-1-β-D-ar

Synthesis of 2′-Deoxy-2′-fluoro-1-β-D-arabinofuranosyl Uracil Derivatives: A Method Suitable for Preparation of [18F]-Labeled Nucleosides.

✍ Mian M. Alauddin; Peter S. Conti; John D. Fissekis; Kyoihci A. Watanabe 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 35 KB 👁 1 views

## Abstract For Abstract see ChemInform Abstract in Full Text.

Multimillicurie preparation of 2-[18F]-f

Multimillicurie preparation of 2-[18F]-fluoro-2-deoxy-D-glucose via nucleophilic displacement with fluorine-18 labelled fluoride. 1. Purification and quality control procedures

✍ M. M. Vora; T. E. Boothe; R. D. Finn; P. J. Kothari; A. M. Emran; S. T. Carroll; 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 French ⚖ 334 KB 👁 1 views

Synthesis of 2-deoxy-2-[18F]-fluoro-β-ma

Synthesis of 2-deoxy-2-[18F]-fluoro-β-mannosyl [18F]-fluoride as a potential imaging probe for Glycosidases

✍ John D. McCarter; Michael J. Adam; Stephen G. Withers 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 French ⚖ 221 KB

## Abstract The mechanisms‐based glycosidase inhibitor 2‐deoxy‐2‐[^18^F]‐fluoro‐β‐mannosyl [^18^F]‐fluoride was synthesized and its covalent binding to __Agrobacterium__ β‐glucosidase was demonstrated __in vitro__.