Synthesis of [18F]2-deoxy-2-fluoro-d-glucose and [18F]3-deoxy-3-fluoro-d-glucose with [18F]fluoride from a water target

✍ Scribed by M. Vogt; R. Weinreich; E.J. Knust; H.-J. Machulla

• Publisher: Elsevier Science
• Year: 1986
• Weight: 213 KB
• Volume: 37
• Category: Article
• ISSN: 0883-2889
• DOI: 10.1016/0883-2889(86)90285-6

✦ Synopsis

A combined study of the labelling methods of two important glucose-derivatives i.e. [18F]2-deoxy-2-fluoro-D-glucose ([laF]2-FDG) and [lSF]3-deoxy-3-fluoro-D-glucose ([18F]3-FDG) is described. Using [ISF]fluoride as reacting agent produced in a water target via the 180(p, n)'SF and ~60(3He, p)~SF reaction, respectively, nucleophilic aliphatic substitution was performed at the corresponding precursors i.e. methyl-4,6-O-benzylidene-2,3-O-cyclic-sulfato-fl-D-mannopyranoside and 1,2: 5,6-di-Oisopropylidene-3-O-trifluoromethanesulfonyl-ct-D-allofuranose. After hydrolysis of the corresponding intermediate [ISF]2-FDG and [18F]3-FDG were obtained as injectable solutions with yields of 22 and 40% (decay corrected), respectively.