๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

[18F]Fluoride from a small cyclotron for the routine synthesis of [18F]2-Fluoro-2-deoxy-d-glucose

โœ Scribed by O.T. DeJesus; J.A. Martin; N.J. Yasillo; S.J. Gatley; M.D. Cooper

Publisher
Elsevier Science
Year
1986
Weight
421 KB
Volume
37
Category
Article
ISSN
0883-2889

No coin nor oath required. For personal study only.

โœฆ Synopsis

[18F]Fluoride was produced via the 18O (p, n) 18F reaction using a low volume stainless steel 18O-water target in a small cyclotron. The average 18F production rate for 60 runs was about 720 microCi/microA-min. A typical bombardment time of 20 min produced 120 mCi of 18F-fluoride. [18F]2-Fluoro-2-deoxy-D-glucose ([18F]2FDG) was prepared using the procedure developed by Tewson [J. Nucl. Med. 24, 718 (1983)] involving a protected cyclic sulfate glucose derivative as precursor. The routine synthesis and quality testing of [18F]2FDG required 1 h and, typically, yields of 30-35 mCi of greater than 95% HPLC-pure product were obtained.

๐Ÿ“œ SIMILAR VOLUMES

Synthesis of [18F]2-deoxy-2-fluoro-d-glu
Synthesis of [18F]2-deoxy-2-fluoro-d-glucose and [18F]3-deoxy-3-fluoro-d-glucose with [18F]fluoride from a water target
โœ M. Vogt; R. Weinreich; E.J. Knust; H.-J. Machulla ๐Ÿ“‚ Article ๐Ÿ“… 1986 ๐Ÿ› Elsevier Science โš– 213 KB

A combined study of the labelling methods of two important glucose-derivatives i.e. [18F]2-deoxy-2-fluoro-D-glucose ([laF]2-FDG) and [lSF]3-deoxy-3-fluoro-D-glucose ([18F]3-FDG) is described. Using [ISF]fluoride as reacting agent produced in a water target via the 180(p, n)'SF and ~60(3He, p)~SF rea

Robotic production of 2-deoxy-2[18F]fluo
Robotic production of 2-deoxy-2[18F]fluoro-d-glucose: A routine method of synthesis using tetrabutylammonium [18F]fluoride
โœ James W. Brodack; Carmen S. Dence; Michael R. Kilbourn; Michael J. Welch ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› Elsevier Science โš– 549 KB

Using existing robotic hardware and software programs developed for the synthesis of several positron-emitting radiopharmaceuticals for PET imaging [Brodack et al. (1988) Appl. Radiat. Isot. 39, 689], the additional automated synthesis of 2-deoxy-2-[18F]fluoro-D-glucose (2-[18F]FDG) has been incorpo

Contamination of 2-deoxy-2-[18F]fluoro-d
Contamination of 2-deoxy-2-[18F]fluoro-d-mannose in the 2-deoxy-2-[18F]fluoro-d-glucose preparations synthesized from [18F]acetyl hypofluorite and [18F]F2
โœ Kiichi Ishiwata; Tatsuo Ido; Hiroaki Nakanishi; Ren Iwata ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› Elsevier Science โš– 364 KB

The presence of 2-deoxy-2-['sF]fluoro-D-mannose (['sF]FDM) in 2-deoxy-2-['\*F]fluoro-o-glucose (['aF]FDG) prepared by the reaction of 3,4,6-tri-0-acetyi-D-glucal (TAG) with ['\*F]acetyl hypofluorite ([r\*F]CHsCOOF) or ['sF]Fr was quantified by radio HPLC analysis of reacetylated ['\*F]FDG. The solve

Alternative synthesis of no-carrier-adde
Alternative synthesis of no-carrier-added 2-deoxy-2-[18F]fluoro-D-glucose using [18F] fluoride ion
โœ Terushi Haradahira; Minoru Maeda; Masaharu Kojima ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 424 KB

Two alternative routes to no-carrier-added synthesis of 2-deoxy-2-[ "F] f luoro-D-glucose (2-18FDG) involving nucleophilic displacements of methyl 3-0-benzyl-4,6-0-benzylidene-2-O-(trifluoromethanesulfonyl~-~-D-mannopyranoside (1) and l,6-anhydro-3,4-di-0-benzyl-2-O-(trifluoromethanesulfonyl)-~-D-ma