Contamination of 2-deoxy-2-[18F]fluoro-d-mannose in the 2-deoxy-2-[18F]fluoro-d-glucose preparations synthesized from [18F]acetyl hypofluorite and [18F]F2

✍ Scribed by Kiichi Ishiwata; Tatsuo Ido; Hiroaki Nakanishi; Ren Iwata

• Publisher: Elsevier Science
• Year: 1987
• Weight: 364 KB
• Volume: 38
• Category: Article
• ISSN: 0883-2889
• DOI: 10.1016/0883-2889(87)90100-6

✦ Synopsis

The presence of 2-deoxy-2-['sF]fluoro-D-mannose (['sF]FDM) in 2-deoxy-2-['*F]fluoro-o-glucose (['aF]FDG) prepared by the reaction of 3,4,6-tri-0-acetyi-D-glucal (TAG) with ['*F]acetyl hypofluorite ([r*F]CHsCOOF) or ['sF]Fr was quantified by radio HPLC analysis of reacetylated ['*F]FDG. The solvent effects on the stereoselectivity of the reaction of TAG with ['"F]CH,COOF were examined in six kinds of solvent. Reaction of TAG with ['8F]CH,COOF in Freon-l 1 results in the least contammatton ot L'"rJrvrvl (45%). The presence of [18F]FDM in the [18F]FDG prepared from TAG with ['sF]F2 was also indicated, but by careful chromatographic separation of hexopyranosyl difluorides the amount was reduced to nearly that resulting from the ['*F]CH,COOF method.