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Synthesis and purification of 2-deoxy-2-[18F]fluoro-d-glucose and 2-deoxy-2-[18F]fluoro-d-mannose: characterization of products by 1H- and 19F-NMR spectroscopy

โœ Scribed by Franz Oberdorfer; William E. Hull; Birgitt C. Traving; Wolfgang Maier-Borst

Publisher
Elsevier Science
Year
1986
Weight
430 KB
Volume
37
Category
Article
ISSN
0883-2889

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โœฆ Synopsis

A procedure has been developed that allows the separation of 2-deoxy-2-[18F]fluoro-D-glucose from 2-deoxy-2-[18F]fluoro-D-mannose employing selectively optimized ion-moderated partition chromatography. Both compounds can be obtained with a greater than 98% chemical and radiochemical purity in about one half-life of 18F. Both the alpha- and beta-anomers of both sugars were completely characterized by high-resolution 1H- and 19F-NMR spectroscopy. Various convenient preparation methods for 2-deoxy-2-[18F]fluoro-D-glucose were compared.

๐Ÿ“œ SIMILAR VOLUMES

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## Abstract A convenient method for the synthesis of ^18^Fโ€2โ€deoxyโ€2โ€fluoroโ€Dโ€glucose (4) and ^18^Fโ€2โ€deoxyโ€2โ€fluoroโ€Dโ€mannose (8) by the direct fluorination of 3,4,6โ€triโ€0โ€acetylโ€Dโ€glucal with ^18^Fโ€F~2~ is described. ^14^Cโ€2โ€deoxyโ€2โ€fluoroโ€Dโ€glucose has been synthesized from ^14^Cโ€3,4,6โ€triโ€0โ€ace

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โœ M. Vogt; R. Weinreich; E.J. Knust; H.-J. Machulla ๐Ÿ“‚ Article ๐Ÿ“… 1986 ๐Ÿ› Elsevier Science โš– 213 KB

A combined study of the labelling methods of two important glucose-derivatives i.e. [18F]2-deoxy-2-fluoro-D-glucose ([laF]2-FDG) and [lSF]3-deoxy-3-fluoro-D-glucose ([18F]3-FDG) is described. Using [ISF]fluoride as reacting agent produced in a water target via the 180(p, n)'SF and ~60(3He, p)~SF rea