Synthesis of 18F-3-deoxy-3-fluoro-D-glucose with reactor-produced 18F
β Scribed by S.John Gatley; William J. Shaughnessy
- Publisher
- Elsevier Science
- Year
- 1980
- Weight
- 295 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0020-708X
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π SIMILAR VOLUMES
455 2 -( 1 8 F ) f l u o r o -2 -d e o x y -d -g l u c o s e p r o d u c e d w i t h a n e l e c t r o n a c c e l e r a t o r .
The synthesis of a pyrimidine analog, 3 0 -deoxy-3 0 -[ 18 F]-fluoro-1-b-d-xylofuranosyluracil ([ 18 F]-FMXU) is reported. 5-Methyluridine 1 was converted to its dimethoxytrityl derivatives 2 and 3 as a mixture. After separation the 2 0 , 5 0 -di-methoxytrityluridine 2 was converted to its 3 0 -trif
18F labelled compounds. Thus, a synthetic route to ("F)2-Deoxy-2-fluoro-~glucose was studied which should run as simple and hot-cell-friendly as possible and shc~uld deliver the sugar with high yield and free of diastereomers, even by use of high I8F acitivities