Pharmacologic prevention of cisplatin nephrotoxicity in rats
β Scribed by Yu. V. Natochin; L. V. Reznik; V. T. Bakhteeva; V. B. Ivanov; E. M. Myazina
- Publisher
- Springer US
- Year
- 1986
- Tongue
- English
- Weight
- 324 KB
- Volume
- 102
- Category
- Article
- ISSN
- 0007-4888
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The influence of acetylcysteine (acβcys) on cisplatin (CP) nephrotoxicity was investigated in female Wistar rats. Administration of 0.6 mg CP 100 g^β1^ body wt. was followed by oliguria and proteinuria, as well as a significant increase of blood urea nitrogen concentration. The i.p. adm
Key words: nephrotoxicity; cisplatin; radical scavengers; methimazole; rat In adult rats 6 mg kg -1 body wt. cisplatin given i.p. was nephrotoxic. Four days of i.p. treatment with 40 mg kg -1 body wt. methimazole, which started 1 day before CP, prevented increases in blood urea nitrogen and in the r