## Abstract Cyclosporine (CsA) causes a dose‐related decrease in renal function in experimental animals and humans. The generation of reactive oxygen species (ROS) has been implicated in CsA‐induced nephrotoxicity. It was previously shown that __Spirulina__, a blue‐green algae, with antioxidant pro
Resveratrol attenuates cisplatin-induced nephrotoxicity in rats
✍ Scribed by Cátia Lira Do Amaral; Heloísa Della Coletta Francescato; Terezila Machado Coimbra; Roberto Silva Costa; Joana D’arc Castania Darin; Lusânia Maria Greggi Antunes; Maria De Lourdes Pires Bianchi
- Publisher
- Springer-Verlag
- Year
- 2007
- Tongue
- English
- Weight
- 439 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0340-5761
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## Abstract Cyclosporin A (CsA) is the prototype of immunosuppressant drugs that have revolutionized the management of all transplantation and autoimmune diseases. Side effects of CsA mainly affecting the kidney but also observed in liver and heart, limit the therapeutic use of this drug after orga
Key words: nephrotoxicity; cisplatin; radical scavengers; methimazole; rat In adult rats 6 mg kg -1 body wt. cisplatin given i.p. was nephrotoxic. Four days of i.p. treatment with 40 mg kg -1 body wt. methimazole, which started 1 day before CP, prevented increases in blood urea nitrogen and in the r
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