Acute cisplatin nephrotoxicity in the rat
✍ Scribed by Michael J. Field; Thor E. Bostrom; Francis Seow; Akos Z. Györy; David J. H. Cockayne
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 503 KB
- Volume
- 414
- Category
- Article
- ISSN
- 0031-6768
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Although mesna afforded protection against the cytotoxicity of cisplatin in Chinese hamster cells, line V-79-753B, in vitro, there was no evidence for protection against nephrotoxicity when this drug combination was examined in the rat. It seems likely that cisplatin-induced nephrotoxicity is mediat
## Abstract The influence of acetylcysteine (ac‐cys) on cisplatin (CP) nephrotoxicity was investigated in female Wistar rats. Administration of 0.6 mg CP 100 g^−1^ body wt. was followed by oliguria and proteinuria, as well as a significant increase of blood urea nitrogen concentration. The i.p. adm