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Beneficial effect of acetylcysteine on cisplatin nephrotoxicity in rats

✍ Scribed by Dorothea Appenroth; Klaus Winnefeld; Heinz Schröter; Michael Rost

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
369 KB
Volume
13
Category
Article
ISSN
0260-437X

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✦ Synopsis

Abstract

The influence of acetylcysteine (ac‐cys) on cisplatin (CP) nephrotoxicity was investigated in female Wistar rats. Administration of 0.6 mg CP 100 g^−1^ body wt. was followed by oliguria and proteinuria, as well as a significant increase of blood urea nitrogen concentration. The i.p. administration of 0.6 mg CP 100 g^−1^ body wt. concomitantly with 100 mg ac‐cys 100 g^−1^ body wt. s.c. completely abolished the nephrotoxic effects of CP. However, following this, the Pt concentration in kidney was decreased significantly by ac‐cys treatment. This was caused by the enhanced urinary excretion of Pt. The same effect on CP nephrotoxicity appeared when CP and ac‐cys were dissolved together in solution prior to injection. It could be shown that in this solution a ligand exchange reaction of CP by ac‐cys started immediately, resulting in increased renal excretion and decreased Pt concentration in kidney.

From our results we concluded that the protective effect of ac‐cys on CP nephrotoxicity is based on the formation of a complex unsuitable for tubular reabsorption.

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