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Protective Effects of Methimazole against Cisplatin-induced Nephrotoxicity in Rats

✍ Scribed by Helmut Bräunlich; Dorothea Appenroth; Christian Fleck

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
159 KB
Volume
17
Category
Article
ISSN
0260-437X

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✦ Synopsis

Key words: nephrotoxicity; cisplatin; radical scavengers; methimazole; rat In adult rats 6 mg kg -1 body wt. cisplatin given i.p. was nephrotoxic. Four days of i.p. treatment with 40 mg kg -1 body wt. methimazole, which started 1 day before CP, prevented increases in blood urea nitrogen and in the renal excretion of proteins. Furthermore, methimazole treatment reduced the oliguric effect of cisplatin and the depression of renal sodium excretion. However, it had no effect on the increased formation of lipid peroxides in cisplatin-damaged kidneys, although repeated treatment with methimazole enhanced the renal glutathione content. Methimazole acts as a radical scavenger, maintaining the glutathione pool in the kidney.

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