Prevention of cisplatin nephrotoxicity by exogenous atrial natriuretic peptide
โ Scribed by Patricia M. Deegan; Mark A. Basinger; Mark M. Jones; Kenneth R. Hande
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 746 KB
- Volume
- 106
- Category
- Article
- ISSN
- 0300-483X
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Atrial Natriuretic Peptide (ANP) and receptors for ANP are widely distributed in many tissues and cell types in vertebrates. ANP has been shown to be internalized into the cytoplasm in several cell types and thus it raises the possibility that it may act on intracellular receptors. Displacement expe
Atrial natriuretic peptide (ANP) is a fluid-regulating peptide hormone that promotes vasorelaxation, natriuresis, and diuresis. The mechanisms for the release of ANP and for its clearance from the circulation play important roles in modulating its biological effects. Recently, we have reported that
## Abstract Atrial natriuretic peptide (ANP), found in mammalian ovarian granulosa cells and oocytes (Kim et al., 1992, 1993), induces the human acrosome reaction (Anderson et al., 1994). The purpose of the present study was to determine whether ANP, as eggderived peptides from sea urchins, can act