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Parkin Plays a Role in Sporadic Parkinson's Disease

✍ Scribed by Dawson, Ted M.; Dawson, Valina L.

Book ID: 121453593
Publisher: S. Karger AG
Year: 2013
Tongue: English
Weight: 76 KB
Volume: 13
Category: Article
ISSN: 1660-2854
DOI: 10.1159/000354307

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## Abstract Mutations in parkin are the second most common known cause of Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that monoubiquitinates and polyubiquitinates proteins to regulate a variety of cellular processes. Loss of parkin's E3 ligase activity is thought to play a pathogenic

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