The role of parkin in familial and spora
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Ted M. Dawson; Valina L. Dawson
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Article
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2010
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John Wiley and Sons
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English
β 122 KB
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## Abstract Mutations in parkin are the second most common known cause of Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that monoubiquitinates and polyubiquitinates proteins to regulate a variety of cellular processes. Loss of parkin's E3 ligase activity is thought to play a pathogenic