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The role of parkin in familial and sporadic Parkinson's disease

✍ Scribed by Ted M. Dawson; Valina L. Dawson

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 122 KB
Volume: 25
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.22798

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✦ Synopsis

Abstract

Mutations in parkin are the second most common known cause of Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that monoubiquitinates and polyubiquitinates proteins to regulate a variety of cellular processes. Loss of parkin's E3 ligase activity is thought to play a pathogenic role in both inherited and sporadic PD. Here, we review parkin biology and pathobiology and its role in the pathogenesis of PD. © 2010 Movement Disorder Society

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