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The role of inheritance in sporadic Parkinson's disease

โœ Scribed by Christopher Hawkes

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
184 KB
Volume
47
Category
Article
ISSN
0364-5134

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Despite the major finding of a genetic defect being responsible for the Parkinson's disease (PD) phenotype in some kindreds with dominantly transmitted PD, the role of inheritance in the cause of the more widespread sporadic form of the disease is still unclear. Twin studies are a classic tool for a

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## Abstract To evaluate possible matrilineal factors in the inheritance of Parkinson's disease, we prospectively identified families in which a parent and multiple siblings had Parkinson's disease. In each of the 5 families identified, the affected parent was the mother (__p__ < 0.03). The age at o