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Parkin mutations in familial and sporadic Parkinson's disease among Indians

✍ Scribed by Shashi Chaudhary; Madhuri Behari; Maninder Dihana; Pazhayannur V. Swaminath; Shyla T. Govindappa; Sachi Jayaram; Vinay Goyal; Arindam Maitra; Uday B. Muthane; R.C. Juyal; B.K. Thelma

Book ID
116820151
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
147 KB
Volume
12
Category
Article
ISSN
1353-8020

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The role of parkin in familial and spora
The role of parkin in familial and sporadic Parkinson's disease
✍ Ted M. Dawson; Valina L. Dawson πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 122 KB πŸ‘ 1 views

## Abstract Mutations in parkin are the second most common known cause of Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that monoubiquitinates and polyubiquitinates proteins to regulate a variety of cellular processes. Loss of parkin's E3 ligase activity is thought to play a pathogenic