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Parkin dosage mutations in patients with early-onset sporadic and familial Parkinson's disease in Chinese: An independent pathogenic role

✍ Scribed by Chaodong Wang; Huili Ma; Xiuli Feng; Shu Xie; Piu Chan


Book ID
113505215
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
643 KB
Volume
1358
Category
Article
ISSN
0006-8993

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## Abstract A multiethnic series of patients with early‐onset Parkinson's disease (EOP) was studied to assess the frequency and nature of __parkin__/PARK2 gene mutations and to investigate phenotype–genotype relationships. Forty‐six EOP probands with an onset age of <45 years, and 14 affected relat