## Abstract Mutations in parkin are the second most common known cause of Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that monoubiquitinates and polyubiquitinates proteins to regulate a variety of cellular processes. Loss of parkin's E3 ligase activity is thought to play a pathogenic
✦ LIBER ✦
Analysis of the parkin deletion in sporadic and familial Parkinson's disease
✍ Scribed by R. Krüger; A. M. M. Vieira-Säcker; W. Kuhn; T. Müller; D. Woitalla; L. Schöls; H. Przuntek; J. T. Epplen; O. Riess
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 68 KB
- Volume
- 106
- Category
- Article
- ISSN
- 1435-1463
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The role of parkin in familial and spora
✍
Ted M. Dawson; Valina L. Dawson
📂
Article
📅
2010
🏛
John Wiley and Sons
🌐
English
⚖ 122 KB
👁 1 views
Prevalence of homozygous deletions of th
✍
Hiroshi Ujike; Mitsutoshi Yamamoto; Akihiro Kanzaki; Kazuya Okumura; Manabu Taka
📂
Article
📅
2001
🏛
John Wiley and Sons
🌐
English
⚖ 19 KB
👁 2 views
Onset and progression of disease in fami
✍
Inzelberg, R. ;Schecthman, E. ;Paleacu, D. ;Zach, L. ;Bonwitt, R. ;Carasso, R.L.
📂
Article
📅
2003
🏛
John Wiley and Sons
🌐
English
⚖ 68 KB
👁 2 views
Defining the ends of Parkin exon 4 delet
✍
Jordi Clarimon; Janel Johnson; Okan Dogu; Wagner Horta; Naheed Khan; Andrew J. L
📂
Article
📅
2005
🏛
John Wiley and Sons
🌐
English
⚖ 117 KB
👁 2 views
Tyrosine hydroxylase polymorphism in fam
✍
V. Planté-Bordeneuve; M. B. Davis; D. M. Maraganore; C. D. Marsden; Professor A.
📂
Article
📅
1994
🏛
John Wiley and Sons
🌐
English
⚖ 283 KB
## Abstract Tyrosine hydroxylase (TH) is a theoretical candidate gene determining susceptibility to Parkinson's disease (PD), and an association between one allele of a polymorphism at the TH locus and sporadic PD has been reported. We investigated TH polymorphism in 44 patients with sporadic PD, 4
Deletions in the Parkin gene and genetic
✍
Elisabeth Leroy; Dimitri Anastasopoulos; Spiridon Konitsiotis; Christian Lavedan
📂
Article
📅
1998
🏛
Springer
🌐
English
⚖ 100 KB