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Imaging movement-related activity in medicated Parkin-associated and sporadic Parkinson’s disease

✍ Scribed by Thilo van Eimeren; Ferdinand Binkofski; Carsten Buhmann; Johann Hagenah; Antonio P. Strafella; Peter P. Pramstaller; Hartwig R. Siebner; Christine Klein

Book ID
116820778
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
130 KB
Volume
16
Category
Article
ISSN
1353-8020

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## Abstract Mutations in parkin are the second most common known cause of Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that monoubiquitinates and polyubiquitinates proteins to regulate a variety of cellular processes. Loss of parkin's E3 ligase activity is thought to play a pathogenic