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Association between Early-Onset Parkinson's Disease and Mutations in the Parkin Gene

✍ Scribed by Lücking, Christoph B.; Dürr, Alexandra; Bonifati, Vincenzo; Vaughan, Jenny; De Michele, Giuseppe; Gasser, Thomas; Harhangi, Biswadjiet S.; Meco, Giuseppe; Denèfle, Patrice; Wood, Nicholas W.; Agid, Yves; Nicholl, D.; Breteler, M.M.B.; Oostra, B.A.; De Mari, M.; Marconi, R.; Filla, A.; Bonnet, A.-M.; Broussolle, E.; Pollak, P.; Rascol, O.; Rosier, M.; Arnould, Arnould; Brice, Alexis


Book ID
120321929
Publisher
Massachusetts Medical Society
Year
2000
Tongue
English
Weight
132 KB
Volume
342
Category
Article
ISSN
0096-6762

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## Abstract A multiethnic series of patients with early‐onset Parkinson's disease (EOP) was studied to assess the frequency and nature of __parkin__/PARK2 gene mutations and to investigate phenotype–genotype relationships. Forty‐six EOP probands with an onset age of <45 years, and 14 affected relat