Early-onset Parkinson’s disease associated with a new parkin mutation in a Spanish family
✍ Scribed by Victoria Alvarez; Luis M. Guisasola; Vanessa G. Moreira; Carlos H. Lahoz; Eliecer Coto
- Book ID
- 117472131
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 162 KB
- Volume
- 313
- Category
- Article
- ISSN
- 0304-3940
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## Abstract A multiethnic series of patients with early‐onset Parkinson's disease (EOP) was studied to assess the frequency and nature of __parkin__/PARK2 gene mutations and to investigate phenotype–genotype relationships. Forty‐six EOP probands with an onset age of <45 years, and 14 affected relat
## Abstract The importance of parkin in early‐onset Parkinson's disease in Japan, Europe, and the United States is well established. The contribution of this gene to the risk of Parkinson's disease in other populations is less well known. To explore the importance of parkin in those of Turkish ance