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A consanguineous Turkish family with early-onset Parkinson's disease and an exon 4 parkin deletion

✍ Scribed by Okan Dogu; Janel Johnson; Dena Hernandez; Melissa Hanson; John Hardy; Hulya Apaydin; Sibel Özekmekçi; Serhan Sevim; Katrina Gwinn-Hardy; Andrew Singleton

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 229 KB
Volume: 19
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.20028

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✦ Synopsis

Abstract

The importance of parkin in early‐onset Parkinson's disease in Japan, Europe, and the United States is well established. The contribution of this gene to the risk of Parkinson's disease in other populations is less well known. To explore the importance of parkin in those of Turkish ancestry, we studied familial cases from that country, and identified a consanguineous family with early‐onset Parkinson's disease due to a homozygous mutation in parkin. © 2004 Movement Disorder Society

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