Noncompartmental determination of the steady-state volume of distribution

✍ Scribed by Leslie Z. Benet; Renato L. Galeazzi

• Publisher: John Wiley and Sons
• Year: 1979
• Tongue: English
• Weight: 474 KB
• Volume: 68
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600680845

✦ Synopsis

Melting

Point 0 1 2 R 2420 202-203O 19O-l9l0 lfin-Ifi2~ para-substituted phenyl and substituted alkyl moieties and the sum of AH, contributions of each functional group present in the R moiety in the ester. Some important AH, values used in our study are shown in Table I (2). A straightforward additivity rule was applied in calculating AHs contributions from the R group. For instance, for the p-benzamidophenyl ester of dinoprostone, the AHs contribution of the phenolic moiety is the sum of 2 X 10.0 for phenyl, 6.5 for >C=O, and 5.6 for -NH-, giving 32.1 kcal/mole.

The relationship between the melting points of 22 dinoprostone C1-esters and 25 dinoprost C1-esters and the (1) W.