Moment analysis has become widely used in recent years as a noncompartmental approach to the estimation of mean residence time (MRT) and steady-state volume of distribution (Vd,,) from single-dose data.1-5 In 1983, the method was first extended to the multiple-dosing situation by Bauer and Gibaldi.6
Noncompartmental determination of the steady-state volume of distribution during multiple dosing
โ Scribed by Ian L. Smith; Jerome J. Schentag
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 253 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0022-3549
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๐ SIMILAR VOLUMES
## Melting Point 0 1 2 R 2420 202-203O 19O-l9l0 lfin-Ifi2~ para-substituted phenyl and substituted alkyl moieties and the sum of AH, contributions of each functional group present in the R moiety in the ester. Some important AH, values used in our study are shown in Table I (2). A straightforward a
The assumption of an instant equilibrium between bound and unbound drug fractions is commonly applied in pharmacokinetic calculations. The equation for the calculation of the steady-state volume of distribution V ss from the time curve of drug concentration in plasma after intravenous bolus dose adm