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Noncompartmental determination of the mean residence time and steady-state volume of distribution during multiple dosing

✍ Scribed by Haiyung Cheng; William J. Jusko

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
233 KB
Volume
80
Category
Article
ISSN
0022-3549

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✦ Synopsis

Moment analysis has become widely used in recent years as a noncompartmental approach to the estimation of mean residence time (MRT) and steady-state volume of distribution (Vd,,) from single-dose data.1-5 In 1983, the method was first extended to the multiple-dosing situation by Bauer and Gibaldi.6 Later, useful alternative approaches for calculating MRT and Vd,, during multiple dosing were proposed by

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