## Melting Point 0 1 2 R 2420 202-203O 19O-l9l0 lfin-Ifi2~ para-substituted phenyl and substituted alkyl moieties and the sum of AH, contributions of each functional group present in the R moiety in the ester. Some important AH, values used in our study are shown in Table I (2). A straightforward a
Noncompartmental determination of the steady-state volume of distribution for any mode of administration
β Scribed by Donald Perrier; Michael Mayersohn
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- English
- Weight
- 236 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Moment analysis has become widely used in recent years as a noncompartmental approach to the estimation of mean residence time (MRT) and steady-state volume of distribution (Vd,,) from single-dose data.1-5 In 1983, the method was first extended to the multiple-dosing situation by Bauer and Gibaldi.6
The problem of finding the steady-state volume of distribution V ss for a linear pharmacokinetic system with peripheral drug elimination is considered. A commonly used equation V ss ΒΌ (D/AUC)\*MRT is applicable only for the systems with central (plasma) drug elimination. The following equation, V ss