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Simplified method for estimating volume of distribution at steady state

✍ Scribed by C. R. Kowarski; A. A. Kowarski

Publisher
John Wiley and Sons
Year
1980
Tongue
English
Weight
234 KB
Volume
69
Category
Article
ISSN
0022-3549

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πŸ“œ SIMILAR VOLUMES

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The problem of finding the steady-state volume of distribution V ss for a linear pharmacokinetic system with peripheral drug elimination is considered. A commonly used equation V ss ΒΌ (D/AUC)\*MRT is applicable only for the systems with central (plasma) drug elimination. The following equation, V ss

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The parameters characterizing tissue distribution refer to the tissue/plasma partition coefficients (Kp), which can be used to derive volume of distribution at steady-state (V(ss)). The effort for predicting drug distribution in human has been further expanded to calculation methods using in vitro-b

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The volume of distribution at steady state is considered to be one of the primary pharmacokinetic measurements obtained from in vivo experiments. This quantity is quite commonly calculated using moments of the observed concentration curve, the process being referred to as noncompartmental analysis.