Simplified physiologically based method to estimate steady-state volume of distribution
β Scribed by Win L. Chiou; Gilbert Lam
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- English
- Weight
- 252 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The parameters characterizing tissue distribution refer to the tissue/plasma partition coefficients (Kp), which can be used to derive volume of distribution at steady-state (V(ss)). The effort for predicting drug distribution in human has been further expanded to calculation methods using in vitro-b
A consistent account of the assumptions of the well-stirred perfusion limited model leads to the equation for the organ tissue that does not coincide with that often presented in books and papers. The difference in pharmacokinetic profiles calculated by the valid and the commonly used equations coul
The steady-state and terminal volumes of distribution, as well as the mean residence time of drug in the body (V ss , V $ , and MRT) are the common pharmacokinetic parameters calculated using the drug plasma concentration-time profile C p (t) following intravenous (i.v. bolus or constant rate infusi